Increased white matter integrity in the corpus callosum in subjects with high genetic loading for schizophrenia
- Authors
- Kim, Sung Nyun; Park, Jun Sung; Jang, Joon Hwan; Jung, Wi Hoon; Shim, Geumsook; Park, Hye Yoon; Hwang, Jae Yeon; Choi, Chi-Hoon; Kang, Do-Hyung; Lee, Jong-Min; Kwon, Jun Soo
- Issue Date
- Apr-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Corpus callosum; Diffusion tensor imaging; Genetic predisposition to disease; Genetic high-risk; Schizophrenia
- Citation
- Progress in Neuro-Psychopharmacology and Biological Psychiatry, v.37, no.1, pp.50 - 55
- Indexed
- SCIE
SCOPUS
- Journal Title
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Volume
- 37
- Number
- 1
- Start Page
- 50
- End Page
- 55
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165984
- DOI
- 10.1016/j.pnpbp.2011.11.015
- ISSN
- 0278-5846
- Abstract
- Objective: White matter abnormalities in the corpus callosum (CC) of schizophrenia have been reported to predate the illness onset. This study aimed to investigate the effect of genetic predisposition on the white matter integrity of the CC, in subjects at genetically high risk for schizophrenia (GHR) and schizophrenia patients. Method: Fractional anisotropy (FA) of the mid-sagittal CC in 22 young GHR, 15 schizophrenia. and 26 control subjects were examined. GHR subjects were defined as non-prodromal individuals who had more than two relatives with schizophrenia within third-degree relatives, one of whom must be a first-degree relative. Results: ANCOVA with age and gender as covariates revealed overall difference of FA in the genu and splenium among the three groups. Post-hoc analysis found significantly increased FA in the genu of GHR subjects compared to controls (corrected p<0.01), whereas schizophrenia patients showed significantly decreased FA in the splenium. Conclusion: The white matter change of the CC in young GHR subjects was the opposite of that in schizophrenia. To consider previous reports on FA decrease in the CC in schizophrenia and the impaired frontal functioning in GHR group, the increased FA may be an indicator of compensatory alteration in white matter integrity in young GHR people.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생체공학전공 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/165984)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.