Recent trends in the treatment of chronic hepatitis C.open access
- Authors
- Jun, Dae Won; Tak, Won Young; Bae, Si Hyun; Lee, Youn Jae
- Issue Date
- Mar-2012
- Publisher
- The Korean Association for the Study of the Liver
- Citation
- The Korean journal of hepatology, v.18, no.1, pp.22 - 28
- Indexed
- SCOPUS
- Journal Title
- The Korean journal of hepatology
- Volume
- 18
- Number
- 1
- Start Page
- 22
- End Page
- 28
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166086
- DOI
- 10.3350/kjhep.2012.18.1.22
- ISSN
- 1738-222X
- Abstract
- Pegylated interferon and ribavirin combination therapy is accepted as the standard antiviral treatment for chronic hepatitis C regardless of HCV genotype. This combination therapy achieves higher response rates than previous therapy, but, nevertheless, a large proportion of patients suffer from treatment failure or adverse events. Recent clinical studies of viral kinetics during antiviral treatment have led to the introduction of response-guided therapy, the concept of 'customized therapy depending on viral response', which focuses on modulation of the treatment period depending on the viral response to create a sustained viral response without unnecessary medication and costs. New upcoming direct-acting antivirals (DAAs) maximize response rate, and triple therapy including DAAs along with pegylated interferon and ribavirin combination therapy could soon be the standard therapy. In this article, we reviewed the factors affecting treatment, response guided treatment, retreatment after failure of standard treatment, management of adverse events during treatment, and new treatment options.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.