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CELL-SPECIFIC SIRNA DELIVERY BY PEPTIDES AND ANTIBODIES
- Issue Date
- Feb-2012
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- cationic peptide; liposome; siRNA delivery; Small interfering RNA; targeted delivery
- Citation
- METHODS IN ENZYMOLOGY, VOL 502: PROTEIN ENGINEERING FOR THERAPEUTICS, PT A, v.502, pp.91 - 122
- Indexed
- SCIE
SCOPUS
- Volume
- 502
- Start Page
- 91
- End Page
- 122
- ISSN
- 0076-6879
- Abstract
- Cellular targeting and intracellular delivery of small interfering RNA (siRNA) remain a critical barrier to the clinical application of RNA interference. This chapter provides an overview of various delivery agents employing protein ligands mediating cell-specific delivery of siRNA. Specifically, the chapter details methodologies for the conjugation of antibody or peptide ligands to 0 the cationic peptide-oligo-9-arginine (ii) the polymer poly(lactic-co-glycolic acid) (PLGA) and (iii) a lipid-vesicle (Liposome).
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Related Researcher
- Lee, Sang Kyung
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)