구강점막에 병변을 보인 사르코이드증 1예

Abstract

Sarcoidosis is a systemic granulomatous disease of unknown origin that may affect multiple organs including the lung, mediastinal and peripheral lymph nodes, eyes, and skin. Although cutaneous manifestations occur in around 25% cases, to our knowledge, oral mucosal involvement is very rare as a leading symptom of sarcoidosis. A 28year-old female presented with localized skin-colored to yellowish indurated papules and plaques on the lower lip mucosa. The lesions were presented for the past month and it progressively enlarged. Histopathologic examination revealed multiple, variable sized, well circumscribed, non-caseating granulomas in the dermis. Serum level of angiotensin converting enzyme was slightly elevated (63.0 U/L) and chest CT revealed bilateral hilar lymphadenopathies. Herein, we report an oral mucosal sarcoidosis, as an initial presentation of the systemic sarcoidosis.