Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma CellsEffect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
- Other Titles
- Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
- Authors
- 황유진; 우혜임; 김인혜; 박동식; 김재현; 엄애선; 황경아
- Issue Date
- Oct-2011
- Publisher
- 경상대학교 농업생명과학연구원
- Keywords
- Ailanthus altissima; Lung cancer; Apoptosis; Bax; Bcl-2; Ailanthus altissima; Lung cancer; Apoptosis; Bax; Bcl-2
- Citation
- 농업생명과학연구, v.45, no.5, pp.91 - 96
- Indexed
- KCI
- Journal Title
- 농업생명과학연구
- Volume
- 45
- Number
- 5
- Start Page
- 91
- End Page
- 96
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167428
- ISSN
- 1598-5504
- Abstract
- We investigated the inhibitory effects of solvent extracts from Ailanthus altissima in A549 human lung cancer cell. A. altissima has been recognized as a traditional healthy food due to its various biological activities against hypertension, strokes, fever, pain, neuralgia, inflammation, and cancer effects. Recently, it has been reported that the extracts of various wild vegetables show strong anti-cancer properties by induction of apoptosis. However, the mechanisms of their cytotoxicity in human lung cancer cells have been poorly understood. The present study was investigated the effects of solvent extracts from A. altissima on cell growth and apoptosis on A549 human lung cancer cells. A treatment of A. altissima inhibited the growth of A549 cells in a dose-dependent manner by inducing apoptosis. Especially, the chloroform fraction showed the highest anti-cancer effect among five kinds of fractions. And also, induction of apoptosis by chloroform fraction were associated with down-regulation of Bcl-2, and up-regulation of pro-apoptotic Bax expression. From these results, A. altissima may have a therapeutic potential in human lung cancer cells and as a functional food.
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Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
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