Time-dependent mussel-inspired functionalization of poly(L-lactide-co-epsilon-caprolactone) substrates for tunable cell behaviors
- Authors
- Shin, Young Min; Lee, Yu Bin; Shin, Heungsoo
- Issue Date
- Oct-2011
- Publisher
- ELSEVIER
- Keywords
- Polydopamine; Bio-inspired material; Poly(L-lactide-co-epsilon-caprolactone); Surface modification; Myoblasts
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.87, no.1, pp.79 - 87
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 87
- Number
- 1
- Start Page
- 79
- End Page
- 87
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167478
- DOI
- 10.1016/j.colsurfb.2011.05.004
- ISSN
- 0927-7765
- Abstract
- Surface properties of biomaterials, such as hydrophobic/hydrophilic balance, chemical group distribution, and topography play important roles in regulation of many cellular behaviors. In this study, we present a bio-inspired coating of synthetic biodegradable poly(L-lactide-co-epsilon-caprolactone)(PLCL) films by using polydopamine for tunable cell behaviors such as adhesion and proliferation. Polydopamine coating decreased the water contact angles of the PLCL film from 75 degrees to 40 degrees, while the amount of coated polydopamine increased from 0.6 mu/cm(2) to 177.9 mu g/cm(2). During the process, dopamine could be directly polymerized on the surface of the PLCL film to form a thin layer or nanosized particles of self-aggregates, which resulted in increase of overall roughness in a time-dependent manner. Characterization of surface atomic composition revealed an increase in signals from nitrogen and the C-N bond, both suggesting homogeneous polydopamine coating with prolonged coating time. The mechanical properties were similar following reaction with polydopamine for a time shorter than 30 min, while alterations in elongation and Young's modulus were observed when the coating time exceeded 240 min. Cell adhesion and proliferation on the polydopamine-coated films were significantly greater than those on the non-coated films. Interestingly, these cell behaviors were significantly improved even under the minimal coating time (5 min). In summary, the bio-inspired coating is of use to generate modular surface of biomaterial based on synthetic poly(alpha-hydroxy ester)s for tunable cell behaviors with optimization of coating time within the range in which their mechanical properties are not compromised.
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