CD24 enhances DNA damage-induced apoptosis by modulating NF-kappa B signaling in CD44-expressing breast cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Ji-hyun | - |
dc.contributor.author | Jang, Kibeom | - |
dc.contributor.author | Lee, Kyung-min | - |
dc.contributor.author | Kim, Minsoon | - |
dc.contributor.author | Kim, Jongbin | - |
dc.contributor.author | Yi, Jae Youn | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Shin, Incheol | - |
dc.date.accessioned | 2022-07-16T18:53:05Z | - |
dc.date.available | 2022-07-16T18:53:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167480 | - |
dc.description.abstract | Cluster of differentiation 24 (CD24) is a small glycosylphosphatidylinositol-linked cell surface molecule that is expressed in a variety of human carcinomas, including breast cancer. To determine the role of CD24 in breast cancer cells, we expressed CD24 in CD24-negative/low and cluster of differentiation 44 (CD44)-positive MDA-MB-231 metastatic breast cancer cells. Forced expression of CD24 resulted in a decrease in c-Raf/mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK)/mitogen-activated protein kinase signaling and reduced cell proliferation. Apoptosis induced by DNA damage was greatly enhanced in MDA-MB-231 CD24 cells as compared with MDA-MB-231 vec cells. CD24 expression efficiently attenuated DNA damage-induced nuclear factor-kappaB (NF-kappa B) signaling in MDA-MB-231 cells. However, in CD24-positive and CD44-negative/low MCF-7 cells, knockdown of CD24 did not significantly affect DNA damage-induced apoptosis nor NF-kappa B signaling. Silencing of CD24 in CD24/CD44-double-positive MDA-MB-468 cells partially rescued DNA damage-induced apoptosis. Transient transfection studies with 293T cells also revealed that CD24 attenuated cell viability and NF-kappa B signaling only when CD44 was cotransfected. These data indicate that CD24 expression potentiated DNA-induced apoptosis by suppressing antiapoptotic NF-kappa B signaling in CD44-expressing cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | CD24 enhances DNA damage-induced apoptosis by modulating NF-kappa B signaling in CD44-expressing breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1093/carcin/bgr173 | - |
dc.identifier.scopusid | 2-s2.0-80053153630 | - |
dc.identifier.wosid | 000295173200010 | - |
dc.identifier.bibliographicCitation | CARCINOGENESIS, v.32, no.10, pp.1474 - 1483 | - |
dc.relation.isPartOf | CARCINOGENESIS | - |
dc.citation.title | CARCINOGENESIS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1474 | - |
dc.citation.endPage | 1483 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | PROGNOSTIC MARKER | - |
dc.subject.keywordPlus | TUMOR CELLS | - |
dc.subject.keywordPlus | CYCLIN D1 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.identifier.url | https://academic.oup.com/carcin/article/32/10/1474/2463725 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.