Genetic Analysis of Complement Component 9 (C9) Polymorphisms with Clearance of Hepatitis B Virus Infection
DC Field | Value | Language |
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dc.contributor.author | Bae, Joon Seol | - |
dc.contributor.author | Pasaje, Charisse Flerida A. | - |
dc.contributor.author | Park, Byung Lae | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Kim, Jeong-Hyun | - |
dc.contributor.author | Park, Tae Joon | - |
dc.contributor.author | Kim, Jason Yongha | - |
dc.contributor.author | Lee, Jin Sol | - |
dc.contributor.author | Koh, In Song | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Kim, Yoon Jun | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.date.accessioned | 2022-07-16T19:11:31Z | - |
dc.date.available | 2022-07-16T19:11:31Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167667 | - |
dc.description.abstract | Background The complement component 9 (C9), a major cytolytic protein in the complement system, plays an important role in the immunological process. However, associations between genetic variations of the complement factor and chronic hepatitis B virus infection still need to be investigated. Aims We hypothesized that genetic variations in the complement component 9 gene can influence the clearance of chronic hepatitis B virus infection, hepatocellular carcinoma occurrence, and onset age of hepatocellular carcinoma. To investigate the relationship between complement component 9 variations and these disease phenotypes, we performed a case-control association analysis in a Korean population. Methods Genetic variations were identified through direct DNA sequencing and genotyped using TaqMan assay (n = 1,103). In order to investigate the relationship of complement component 9 with chronic hepatitis B virus clearance and hepatocellular carcinoma occurrence, differences in SNP and haplotype frequency distributions were analyzed using logistic and multiple regression analyses with adjusted age and gender as covariates. Results Although +23189C > T polymorphism in exon 4 and C9_ht2 [T-G-C-A-C] were significantly associated with clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence, the association signals were not retained after multiple testing corrections. Conclusions We conclude that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. Although this preliminary result provides meaningful information, further functional investigations in other genetic factors for pathway analyses are required. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Genetic Analysis of Complement Component 9 (C9) Polymorphisms with Clearance of Hepatitis B Virus Infection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, In Song | - |
dc.identifier.doi | 10.1007/s10620-011-1657-3 | - |
dc.identifier.scopusid | 2-s2.0-80054725292 | - |
dc.identifier.wosid | 000294800100031 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, v.56, no.9, pp.2735 - 2741 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.title | DIGESTIVE DISEASES AND SCIENCES | - |
dc.citation.volume | 56 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2735 | - |
dc.citation.endPage | 2741 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | PUTATIVE ASSOCIATION | - |
dc.subject.keywordPlus | HBV INFECTION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | DEFICIENCIES | - |
dc.subject.keywordAuthor | Complement component 9 | - |
dc.subject.keywordAuthor | Hepatitis B virus | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Single nucleotide polymorphism | - |
dc.subject.keywordAuthor | Haplotypes | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10620-011-1657-3 | - |
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