Genetic Analysis of Complement Component 9 (C9) Polymorphisms with Clearance of Hepatitis B Virus Infection
- Authors
- Bae, Joon Seol; Pasaje, Charisse Flerida A.; Park, Byung Lae; Cheong, Hyun Sub; Kim, Jeong-Hyun; Park, Tae Joon; Kim, Jason Yongha; Lee, Jin Sol; Koh, In Song; Lee, Hyo-Suk; Kim, Yoon Jun; Shin, Hyoung Doo
- Issue Date
- Sep-2011
- Publisher
- SPRINGER
- Keywords
- Complement component 9; Hepatitis B virus; Hepatocellular carcinoma; Single nucleotide polymorphism; Haplotypes
- Citation
- DIGESTIVE DISEASES AND SCIENCES, v.56, no.9, pp.2735 - 2741
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIGESTIVE DISEASES AND SCIENCES
- Volume
- 56
- Number
- 9
- Start Page
- 2735
- End Page
- 2741
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167667
- DOI
- 10.1007/s10620-011-1657-3
- ISSN
- 0163-2116
- Abstract
- Background The complement component 9 (C9), a major cytolytic protein in the complement system, plays an important role in the immunological process. However, associations between genetic variations of the complement factor and chronic hepatitis B virus infection still need to be investigated. Aims We hypothesized that genetic variations in the complement component 9 gene can influence the clearance of chronic hepatitis B virus infection, hepatocellular carcinoma occurrence, and onset age of hepatocellular carcinoma. To investigate the relationship between complement component 9 variations and these disease phenotypes, we performed a case-control association analysis in a Korean population. Methods Genetic variations were identified through direct DNA sequencing and genotyped using TaqMan assay (n = 1,103). In order to investigate the relationship of complement component 9 with chronic hepatitis B virus clearance and hepatocellular carcinoma occurrence, differences in SNP and haplotype frequency distributions were analyzed using logistic and multiple regression analyses with adjusted age and gender as covariates. Results Although +23189C > T polymorphism in exon 4 and C9_ht2 [T-G-C-A-C] were significantly associated with clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence, the association signals were not retained after multiple testing corrections. Conclusions We conclude that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. Although this preliminary result provides meaningful information, further functional investigations in other genetic factors for pathway analyses are required.
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