Population attributable fraction of infection-related cancers in Koreaopen access
- Authors
- Shin, Aesun; Park, Seek Ryun; Shin, Hai-rim; Park, Eui Ho; Park, Sue Kyung; Oh, Jin-Kyoung; Lim, Min Kyung; Choi, Bo Yul; Boniol, Mathieu; Boffetta, Paolo
- Issue Date
- Jun-2011
- Publisher
- OXFORD UNIV PRESS
- Keywords
- cancer burden; infection; population attributable fraction
- Citation
- ANNALS OF ONCOLOGY, v.22, no.6, pp.1435 - 1442
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 22
- Number
- 6
- Start Page
- 1435
- End Page
- 1442
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168308
- DOI
- 10.1093/annonc/mdq592
- ISSN
- 0923-7534
- Abstract
- Background: A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population. Materials and methods: The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007. Results: The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV. Conclusion: Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.
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