Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor
DC Field | Value | Language |
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dc.contributor.author | Kim, Chul Han | - |
dc.contributor.author | Lee, Jang Hyun | - |
dc.contributor.author | Won, Jong Ho | - |
dc.contributor.author | Cho, Moon Kyun | - |
dc.date.accessioned | 2022-07-16T20:29:04Z | - |
dc.date.available | 2022-07-16T20:29:04Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168321 | - |
dc.description.abstract | We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of Sprague-Dawley rats. One site was covered with a 3D collagen gel containing 2 x 10(6) MSCs (MSCs+/3D collagen+). Another site was replaced with a 3D collagen gel without MSCs and the third site was left empty. The wound size was significantly reduced in the MSCs+/3D collagen+ sites. MSCs+/3D collagen+ sites exhibited the most neovascularization. FISH showed that Y-chromosome possessing cells were found within the dermis of MSCs+/3D collagen+ sites. Gelatin zymography revealed that the most intense expression of MMP-9 was detected early in the MSCs+/3D collagen+ sites. Our results indicate that MSCs upregulate the early expression of MMP-9 which induces the early mobilization of VEGF. Thus, MSCs appear to accelerate significantly wound healing via early activation of MMP-9 and VEGF. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jang Hyun | - |
dc.identifier.doi | 10.3346/jkms.2011.26.6.726 | - |
dc.identifier.scopusid | 2-s2.0-79958273205 | - |
dc.identifier.wosid | 000291358200004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.6, pp.726 - 733 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 26 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 726 | - |
dc.citation.endPage | 733 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001556567 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordPlus | METALLOPROTEINASES | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MYOCARDIUM | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | MURINE | - |
dc.subject.keywordAuthor | Mesenchymal Stem Cells | - |
dc.subject.keywordAuthor | Wound Healing | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2011.26.6.726 | - |
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