Mesenchymal Stem Cells Improve Wound Healing In Vivo via Early Activation of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factoropen access
- Authors
- Kim, Chul Han; Lee, Jang Hyun; Won, Jong Ho; Cho, Moon Kyun
- Issue Date
- Jun-2011
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Mesenchymal Stem Cells; Wound Healing
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.6, pp.726 - 733
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 26
- Number
- 6
- Start Page
- 726
- End Page
- 733
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168321
- DOI
- 10.3346/jkms.2011.26.6.726
- ISSN
- 1011-8934
- Abstract
- We investigated the effects of mesenchymal stem cells (MSCs) on wound healing using a three-dimensional (3D) collagen gel scaffold. Three circular full-thickness skin defects were created on the back of Sprague-Dawley rats. One site was covered with a 3D collagen gel containing 2 x 10(6) MSCs (MSCs+/3D collagen+). Another site was replaced with a 3D collagen gel without MSCs and the third site was left empty. The wound size was significantly reduced in the MSCs+/3D collagen+ sites. MSCs+/3D collagen+ sites exhibited the most neovascularization. FISH showed that Y-chromosome possessing cells were found within the dermis of MSCs+/3D collagen+ sites. Gelatin zymography revealed that the most intense expression of MMP-9 was detected early in the MSCs+/3D collagen+ sites. Our results indicate that MSCs upregulate the early expression of MMP-9 which induces the early mobilization of VEGF. Thus, MSCs appear to accelerate significantly wound healing via early activation of MMP-9 and VEGF.
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