Prospective Evaluation of the Clinical Utility of Interferon-gamma Assay in the Differential Diagnosis of Intestinal Tuberculosis and Crohn's Disease
- Authors
- Kim, Beom Jin; Choi, Yong Sung; Jang, Byung Ik; Park, Young Sook; Kim, Won Ho; Kim, You Sun; Jung, Sung-Ae; Han, Dong Soo; Kim, Joo Sung; Choi, Jai Hyun; Choi, Chang Hwan; Jeen, Yoon Tae; Cheon, Jae Hee; Ye, Byong Duk; Yang, Suk-Kyun; Kim, Young-Ho
- Issue Date
- Jun-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- intestinal tuberculosis; Crohn' s disease; diagnosis; interferon-gamma assay; tuberculin skin test
- Citation
- INFLAMMATORY BOWEL DISEASES, v.17, no.6, pp.1308 - 1313
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATORY BOWEL DISEASES
- Volume
- 17
- Number
- 6
- Start Page
- 1308
- End Page
- 1313
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168354
- DOI
- 10.1002/ibd.21490
- ISSN
- 1078-0998
- Abstract
- Background: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is challenging. This study prospectively evaluated the clinical utility of the QuantiFERON-TB gold test (QFT) in the differential diagnosis of ITB and CD, and compared it with the clinical utility of the tuberculin skin test (TST). Methods: Patients with suspected ITB or CD on colonoscopic findings were enrolled from 13 hospitals in Korea between June 2007 and November 2008. A QFT and TST were performed. When the initial diagnosis was not confirmed, 2-3 months of empiric antituberculous therapy was administered. Results: In all, 128 patients were analyzed; 64 patients had ITB and 64 patients had CD. The median age of patients with ITB was greater than the patients with CD (47 years versus 31 years, P < 0.001). The positive rate for the QFT and TST (>= 10 mm) in patients with ITB was significantly higher than patients with CD (67% versus 9% and 69% versus 16%, respectively; P < 0.001). The QFT and TST had good agreement (kappa = 0.724, P < 0.001). The diagnostic validity of QFT in ITB had a 67% sensitivity, 90% specificity, 87% positive predictive value, and 73% negative predictive value. There was no difference in these parameters between the QFT and TST. The likelihood ratio for a positive QFT was higher than a positive TST in the diagnosis of ITB (7.1 and 4.4, respectively). Conclusions: The QFT is a limited but useful diagnostic aid in combination with the TST in the diagnosis of ITB.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168354)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.