Analysis of Prognostic Factors of Pediatric-Type Sarcomas in Adult Patients
- Authors
- Ahn, Hee Kyung; Uhm, Ji eun; Lee, Jeeyun; Lim, Do Hoon; Seo, Sung Wook; Sung, Ki-Sun; Lee, Su Jin; Lee, Duk Joo; Baek, Kyung Kee; Kim, Won-Seog; Park, Joon Oh
- Issue Date
- May-2011
- Publisher
- KARGER
- Keywords
- Pediatric-type sarcoma; Rhabdomyosarcoma; Ewing' s sarcoma; Primitive neuroectodermal tumor family; Desmoplastic small round-cell tumor; Prognosis
- Citation
- ONCOLOGY, v.80, no.1-2, pp.21 - 28
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOLOGY
- Volume
- 80
- Number
- 1-2
- Start Page
- 21
- End Page
- 28
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168456
- DOI
- 10.1159/000327222
- ISSN
- 0030-2414
- Abstract
- Objective: Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. Methods: We retrospectively reviewed pediatric-type sarcoma patients older than 15 years at a single institution. Results: A total of 84 consecutive patients between 1995 and 2009 were identified at the Samsung Medical Center, Seoul, Korea. Median age was 30 years with a range of 15-74 years. Forty-seven patients (56.0%) were diagnosed with Ewing's sarcoma/primitive neuroectodermal tumor family, 34 (40.5%) with rhabdomyosarcoma and 3 (3.6%) with desmoplastic round-cell tumor. Median follow-up duration was 5.9 years. Median overall survival for all patients was 33.1 months (95% CI 13.5-52.7) and median event-free survival for all patients was 14.4 months (95% CI 5.9-22.9 months). Multivariate analysis revealed that localized disease was a significant independent prognostic factor for longer overall survival (hazard ratio 0.30, 95% CI 0.14-0.66, p = 0.003), and favorable primary tumor sites were associated with longer event-free survival (hazard ratio 0.33, 95% CI 0.11-0.98, p = 0.045). Conclusion: We identified the prognostic variables which may facilitate risk-adapted therapies for this rare adult sarcoma group, which should be further investigated.
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