Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
- Authors
- Kang, Hye-Ryun; Jee, Young Koo; Kim, Yon-Soo; Lee, Chang Hwa; Jung, Jae-Woo; Kim, Sae Hoon; Park, Heung-Woo; Chang, Yoon-Seok; Jang, In-Jin; Cho, Sang-Heon; Min, Kyung-Up; Kim, Sang-Heon; Lee, Kyung Wha
- Issue Date
- May-2011
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- allopurinol; drug-induced hypersensitivity syndrome; human leukocyte antigen class I; Stevens-Johnson syndrome; toxic epidermal necrolysis
- Citation
- PHARMACOGENETICS AND GENOMICS, v.21, no.5, pp.303 - 307
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOGENETICS AND GENOMICS
- Volume
- 21
- Number
- 5
- Start Page
- 303
- End Page
- 307
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168516
- DOI
- 10.1097/FPC.0b013e32834282b8
- ISSN
- 1744-6872
- Abstract
- Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds. To explore genetic markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. Frequencies of B*5801 [92.0 vs. 10.5%, P(c) = 2.45 x 10(-11), odds ratio (OR) = 97.8], Cw*0302 (92.0 vs. 12.3%, P(c) = 9.39 x 10(-11), OR = 82.1), and A*3303 (88.0 vs. 26.3%, P(c) = 3.31 x 10(-6), OR = 20.5) were significantly higher in SCARs compared with tolerant controls. In contrast, A*0201 was not found in SCARs patients despite relatively high frequency in tolerant controls (29.8%). We found strong positive association of HLA-B*5801 and negative association of HLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168516)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.