Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bhang, Suk Ho | - |
dc.contributor.author | Sun, Ah-Young | - |
dc.contributor.author | Yang, Hee Seok | - |
dc.contributor.author | Rhim, Taiyoun | - |
dc.contributor.author | Kim, Dong-Ik | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2022-07-16T21:15:05Z | - |
dc.date.available | 2022-07-16T21:15:05Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168737 | - |
dc.description.abstract | Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhim, Taiyoun | - |
dc.identifier.doi | 10.1007/s10529-010-0492-5 | - |
dc.identifier.scopusid | 2-s2.0-79952743354 | - |
dc.identifier.wosid | 000288548900028 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY LETTERS, v.33, no.4, pp.845 - 851 | - |
dc.relation.isPartOf | BIOTECHNOLOGY LETTERS | - |
dc.citation.title | BIOTECHNOLOGY LETTERS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 845 | - |
dc.citation.endPage | 851 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ENDOTHELIAL PROGENITOR CELLS | - |
dc.subject.keywordPlus | WOUND REPAIR | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | Fibroblast growth factor 2 | - |
dc.subject.keywordAuthor | Heparin-conjugated fibrin | - |
dc.subject.keywordAuthor | Skin regeneration | - |
dc.subject.keywordAuthor | Vascularization | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10529-010-0492-5 | - |
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