Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin
- Authors
- Bhang, Suk Ho; Sun, Ah-Young; Yang, Hee Seok; Rhim, Taiyoun; Kim, Dong-Ik; Kim, Byung-Soo
- Issue Date
- Apr-2011
- Publisher
- SPRINGER
- Keywords
- Fibroblast growth factor 2; Heparin-conjugated fibrin; Skin regeneration; Vascularization
- Citation
- BIOTECHNOLOGY LETTERS, v.33, no.4, pp.845 - 851
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 33
- Number
- 4
- Start Page
- 845
- End Page
- 851
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168737
- DOI
- 10.1007/s10529-010-0492-5
- ISSN
- 0141-5492
- Abstract
- Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis.
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