류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 지종대 | - |
dc.contributor.author | 김태환 | - |
dc.contributor.author | 이빛나라 | - |
dc.contributor.author | 최성재 | - |
dc.contributor.author | 이영호 | - |
dc.contributor.author | 송관규 | - |
dc.date.accessioned | 2022-07-16T21:24:32Z | - |
dc.date.available | 2022-07-16T21:24:32Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168848 | - |
dc.description.abstract | Objective. To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB)CD14+ osteoclast precursors. Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis,the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR. Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis- related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors. Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한류마티스학회 | - |
dc.title | 류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현 | - |
dc.title.alternative | Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 김태환 | - |
dc.identifier.doi | 10.4078/jrd.2011.18.1.11 | - |
dc.identifier.bibliographicCitation | 대한류마티스학회지, v.18, no.1, pp.11 - 18 | - |
dc.relation.isPartOf | 대한류마티스학회지 | - |
dc.citation.title | 대한류마티스학회지 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 11 | - |
dc.citation.endPage | 18 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001540635 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Synovial osteoclast precursors | - |
dc.subject.keywordAuthor | Osteoclastogenesis | - |
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