류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages
- Other Titles
- Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages
- Authors
- 지종대; 김태환; 이빛나라; 최성재; 이영호; 송관규
- Issue Date
- Mar-2011
- Publisher
- 대한류마티스학회
- Keywords
- Rheumatoid arthritis; Synovial osteoclast precursors; Osteoclastogenesis
- Citation
- 대한류마티스학회지, v.18, no.1, pp.11 - 18
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 18
- Number
- 1
- Start Page
- 11
- End Page
- 18
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168848
- DOI
- 10.4078/jrd.2011.18.1.11
- ISSN
- 2093-940X
- Abstract
- Objective. To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB)CD14+ osteoclast precursors.
Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis,the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR.
Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis- related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors.
Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors.
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