Upregulation of interleukin-1 beta production by 1,25-Dihydroxyvitamin D-3 in activated human macrophages
- Authors
- Lee, Bit-Na-Ra; Kim, Tae-Hwan; Jun, Jae-Bum; Yoo, Dae-Hyun; Woo, Jin-Hyun; Choi, Sung Jae; Lee, Young Ho; Song, Gwan Gyu; Kim, Yongjin; Lee, Ji Young; Sohn, Jeongwon; Ji, Jong Dae
- Issue Date
- Mar-2011
- Publisher
- SPRINGER
- Keywords
- 1,25-Dihydroxyvitamin D-3; IL-1 beta; Macrophages; Inflammation
- Citation
- MOLECULAR BIOLOGY REPORTS, v.38, no.3, pp.2193 - 2201
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 38
- Number
- 3
- Start Page
- 2193
- End Page
- 2201
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168884
- DOI
- 10.1007/s11033-010-0348-z
- ISSN
- 0301-4851
- Abstract
- 1,25-Dihydroxyvitamin D-3 (1,25(OH)(2)D-3) plays important roles in the immune system. In contrast to its well known function in the adaptive immune system, much less is known about the immunoregulatory effects of 1,25(OH)(2)D-3 in the innate immune system, especially on activated human macrophages. Here we found that 1,25(OH)(2)D-3 strongly stimulated the production of interleukin-1 beta (IL-1 beta) in PMA-differentiated U937 cells and human monocyte-derived macrophages treated with lipopolysaccharide (LPS) or PMA. In this study, Erk1/2 appeared to mediate 1,25(OH)(2)D-3-induced expression of IL-1 beta. Parallel to the increased production of IL-1 beta, 1,25(OH)(2)D-3 increased the expression and phosphorylation of the CCAAT enhancer-binding protein beta (C/EBP beta), which is one of the key transcriptional regulatory factors for IL-1 beta transcription. These results suggest that 1,25(OH)(2)D-3 may function as a proinflammatory molecule in inflammatory macrophages.
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