Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma
- Authors
- Kim, Sang-Heon; Kim, Tae Hyung; Lee, Ji Seon; Koo, Tai Yeon; Lee, Chang Beom; Yoon, Ho Joo; Shin, Dong Ho; Park, Sung Soo; Sohn, Jang Won
- Issue Date
- Mar-2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- adipokines; adipose-derived hormones; adiposity; airway inflammation; body mass index; exhaled nitric oxide
- Citation
- JOURNAL OF ASTHMA, v.48, no.2, pp.177 - 182
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ASTHMA
- Volume
- 48
- Number
- 2
- Start Page
- 177
- End Page
- 182
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168955
- DOI
- 10.3109/02770903.2010.529223
- ISSN
- 0277-0903
- Abstract
- Background. Epidemiological studies have shown that obesity//adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity//adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity//adiposity in nonasthmatic healthy adults. Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity//adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses. Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-alpha alpha, or interleukin (IL)-6 was observed. Conclusions. These findings suggest that in healthy subjects without asthma, obesity//adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.
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