Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
HISTAMINE AND TNF-alpha RELEASE BY RAT PERITONEAL MAST CELLS STIMULATED WITH TRICHOMONAS VAGINALISopen access
- Authors
- Im, S. J.; Ahn, M. N.; Han, I. H.; Song, H. O.; Kim, Y. S.; Kim, H. M.; Ryu, J. S.
- Issue Date
- Feb-2011
- Publisher
- EDP SCIENCES S A
- Keywords
- Trichomonas vaginalis; rat; mast cell; migration; histamine; TNF-alpha
- Citation
- PARASITE, v.18, no.1, pp.49 - 55
- Indexed
- SCIE
SCOPUS
- Journal Title
- PARASITE
- Volume
- 18
- Number
- 1
- Start Page
- 49
- End Page
- 55
- ISSN
- 1252-607X
- Abstract
- Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.
- Files in This Item
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Kim, Yong seok
- COLLEGE OF MEDICINE (DEPARTMENT OF BIOCHEMISTRY & MOLECULAR BIOLOGY)