A Novel Insertion Sequence, ISAba10, Inserted into ISAba1 Adjacent to the blaₒₓₐ₋₂₃ Gene and Disrupting the Outer Membrane Protein Gene carO in Acinetobacter baumannii
- Authors
- Lee, Yang soon; Kim, Chang-Ki; Lee, Hyukmin; Jeong, Seok Hoon; Yong, Dongeun; Lee, Kyungwon
- Issue Date
- Jan-2011
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.55, no.1, pp.361 - 363
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Volume
- 55
- Number
- 1
- Start Page
- 361
- End Page
- 363
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169194
- DOI
- 10.1128/AAC.01672-09
- ISSN
- 0066-4804
- Abstract
- We investigated an outbreak caused by carbapenem-resistant Acinetobacter baumannii carrying the blaₒₓₐ₋₂₃ gene. A novel insertion sequence (IS), named ISAba10, was found to be inserted into the ISAba1 element preceding the blaₒₓₐ₋₂₃ gene in a group of isolates showing higher carbapenem MICs. The presence of ISAba10 was associated with increased OXA-23 expression, likely by providing additional promoter sequences. ISAba10 was also inserted into the carO outer membrane protein gene in most of these isolates.
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