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Claudin-11 expression increased in spermatogenic defect in human testes
- Issue Date
- Jan-2011
- Publisher
- Elsevier BV
- Keywords
- Claudin-11; human; Sertoli cells; testis; tight junction
- Citation
- Fertility and Sterility, v.95, no.1, pp 385 - 388
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Fertility and Sterility
- Volume
- 95
- Number
- 1
- Start Page
- 385
- End Page
- 388
- ISSN
- 0015-0282
1556-5653
- Abstract
- Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis.
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