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Claudin-11 expression increased in spermatogenic defect in human testes
- Issue Date
- Jan-2011
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Claudin-11; human; Sertoli cells; testis; tight junction
- Citation
- FERTILITY AND STERILITY, v.95, no.1, pp.385 - 388
- Indexed
- SCIE
SCOPUS
- Journal Title
- FERTILITY AND STERILITY
- Volume
- 95
- Number
- 1
- Start Page
- 385
- End Page
- 388
- ISSN
- 0015-0282
- Abstract
- Expression of claudin-11, which builds up blood-testis barrier (BTB), was increased in decreased spermatogenesis, including in hypospermatogenesis, spermatocytic and maturation arrest, and Sertoli cell only (SCO) testes. Increased claudin-11 immunoreactivity was observed at the inter-Sertoli tight junctions in maturation arrest and in the cytoplasm of Sertoli cells in SCO. The late spermatogenic wave may negatively regulate claudin-11 gene activation and the subcellular localization of claudin-11 in Sertoli cells, thus altering the BTB in the human testis.
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Related Researcher
- Gye, Myung Chan
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)