Carbapenem-non-susceptible Acinetobacter baumannii of sequence type 92 or its single-locus variants with a G428T substitution in zone 2 of the rpoB gene
DC Field | Value | Language |
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dc.contributor.author | Lee, Yang soon | - |
dc.contributor.author | Lee, Jinhwa | - |
dc.contributor.author | Jeong, Seok Hoon | - |
dc.contributor.author | Lee, Jonghan | - |
dc.contributor.author | Bae, Il Kwon | - |
dc.contributor.author | Lee, Kyungwon | - |
dc.date.accessioned | 2022-07-16T22:28:26Z | - |
dc.date.available | 2022-07-16T22:28:26Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169337 | - |
dc.description.abstract | Objectives To investigate the epidemiological traits of carbapenem-non-susceptible Acinetobacter baumannii (CNSAB) and the usefulness of phylogenetic grouping based on partial rpoB gene sequencing in defining the epidemiological traits of CNSAB. Methods A total of 547 non-duplicate clinical isolates of Acinetobacter spp. were collected from 19 hospitals in Korea in 2008. Detection of genes encoding OXA carbapenemases and metallo-β-lactamases was performed by PCR. The epidemiological relationships of the isolates were investigated by multilocus sequence typing and repetitive-sequence-based PCR. The 450 bp sequence (zone 2) of the rpoB gene was amplified and sequenced. Results Molecular characterization of the 272 CNSAB isolates identified five sequence types (STs): ST92, ST75, ST137, ST138 and ST69. The first four of these STs were clustered into clonal complex (CC) 92, sharing alleles at six of seven housekeeping gene loci; ST69 shared alleles at five of seven loci. CNSAB of CC92 carried the blaₒₓₐ₋₂₃ gene (n = 169), the blaₒₓₐ₋₅₁-like gene preceded by ISAba1 (n = 89) or both (n = 14). Notably, all CNSAB isolates carried a G428T substitution in zone 2 of the rpoB gene. Conclusions CNSAB isolates of CC92 with the G428T substitution in zone 2 of the rpoB gene are disseminated nationwide in Korea. A. baumannii with the single nucleotide substitution may be more likely to acquire carbapenem resistance than are other isolates. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Carbapenem-non-susceptible Acinetobacter baumannii of sequence type 92 or its single-locus variants with a G428T substitution in zone 2 of the rpoB gene | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Yang soon | - |
dc.identifier.doi | 10.1093/jac/dkq402 | - |
dc.identifier.scopusid | 2-s2.0-78650389101 | - |
dc.identifier.wosid | 000285417700008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, v.66, pp.66 - 72 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.title | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.volume | 66 | - |
dc.citation.startPage | 66 | - |
dc.citation.endPage | 72 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | POLYMERASE-CHAIN-REACTION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | COLISTIN | - |
dc.subject.keywordPlus | SPREAD | - |
dc.subject.keywordPlus | CLONE | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordPlus | RATES | - |
dc.subject.keywordPlus | SPP. | - |
dc.subject.keywordAuthor | Clonal complex 92 | - |
dc.subject.keywordAuthor | European clone II | - |
dc.subject.keywordAuthor | Multilocus sequence typing | - |
dc.identifier.url | https://academic.oup.com/jac/article/66/1/66/724734 | - |
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