I, II병기 비소세포폐암의 예후에 대한 수술 전 양전자방출 컴퓨터 단층촬영기 의 임상적 의의open accessPrognostic Value of Preoperative Positron Emission Tomography- Computed Tomography in Surgically Resected Stage I and II Non- Small Cell Lung Cancer
- Other Titles
- Prognostic Value of Preoperative Positron Emission Tomography- Computed Tomography in Surgically Resected Stage I and II Non- Small Cell Lung Cancer
- Authors
- 송선헌; 손장원; 곽현정; 김사일; 김상헌; 김태형; 윤호주; 신동호; 최윤영; 박성수
- Issue Date
- 2011
- Publisher
- 대한결핵및호흡기학회
- Keywords
- Carcinoma; Non-Small Cell Lung; Positron-Emission Tomography; Prognosis
- Citation
- Tuberculosis and Respiratory Diseases, v.71, no.6, pp.425 - 430
- Indexed
- SCOPUS
KCI
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 71
- Number
- 6
- Start Page
- 425
- End Page
- 430
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169350
- DOI
- 10.4046/trd.2011.71.6.425
- ISSN
- 1738-3536
- Abstract
- Background: High 2-[¹⁸F] fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) is a prognostic factor for poor survival in non-small cell lung cancer (NSCLC), especially in Stage I. We determined whether the high FDG uptake value of a primary tumor was associated with recurrence and death in patients with resected Stage I and Stage II NSCLC.
Methods: We identified consecutive patients who underwent complete surgical resection for Stage I and II NSCLC between 2006 and 2009, who had preoperative PET-CT, and reviewed clinical records retrospectively. FDG uptake was measured as the maximal standardized uptake value (SUVmax) for body weight. Patients were divided into two groups based on SUVmax: (i) above or (ii) below the cut-off value (SUVmax=5.9) determined by a receiver operating characteristic (ROC) curve.
Results: Of 57 patients who were enrolled consecutively, 32 (56%) had Stage I NSCLC and 25 (44%) had Stage II. The 5-year recurrence-free survival (RFS) for patients with high (≥5.9) and low (<5.9) SUVmax were 31%and 57%, respectively (p=0.014). The 5-year overall survival (OS) rates were 39% and 60%, respectively (p=0.029). In univariate analyses, SUVmax (p=0.014), T staging (p=0.025), and differentiation of tumor tissue (p=0.034) were significantly associated with RFS. But, multivariate analyses did not show that SUVmax was an independently significant factor for RFS (p=0.180).
Conclusion: High FDG uptake on PET-CT is not an independent prognostic factor for poor outcomes (disease recurrence in patients with resected Stage I and II NSCLC).
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