Maternal exercise reduces hyperthermia-induced apoptosis in developing mouse brain
- Authors
- Lee, Jin; Cho, Joon Yong; Oh, Sang Duk; Kim, Sung Min; Shim, Yun Taek; Park, Sok; Kim, Won Kyu
- Issue Date
- 2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- maternal hyperthermia; maternal exercise; apoptosis; heat shock proteins; Hsp70 knockout (KO) mouse embryos
- Citation
- INTERNATIONAL JOURNAL OF HYPERTHERMIA, v.27, no.5, pp.445 - 452
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HYPERTHERMIA
- Volume
- 27
- Number
- 5
- Start Page
- 445
- End Page
- 452
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169418
- DOI
- 10.3109/02656736.2011.569967
- ISSN
- 0265-6736
- Abstract
- Purpose: Hyperthermia-induced apoptosis is mediated by mitochondrial pathway, and is temporally correlated with alterations in mitochondrial morphology in neuroepithelial cells. In addition, regular exercise up-regulates heat shock proteins (HSPs) that inhibit apoptosis. However, embryo-protective effects of maternal exercise against heat exposure during pregnancy have not been fully understood yet.
Materials and methods: To investigate the role of maternal exercise in protecting embryos from hyperthermia, we measured apoptosis-related factors and HSPs in Hsp70 knockout mouse embryos. Pregnant mice were divided into control, exercise, hyperthermia-after-exercise, and hyperthermia groups. Where appropriate the swimming exercise was performed for 5-10 min/day from embryonic day (ED) 1 to ED 8, and hyperthermia (43℃, 5 min) was induced on ED 8. To characterise the effects of maternal exercise on apoptosis-related factors and HSPs, we performed western blotting and transmission electron microscopy.
Results: Caspase-9, -7, -3 and Bax were down-regulated in the hyperthermia-after-exercise group and Bcl-2, Hsp27 and Hsp110 were up-regulated. The number of apoptotic cells was markedly reduced in the hyperthermia-after-exercise group.
Conclusions: Maternal exercise plays an important role in inhibiting apoptotic cell death in embryos against hyperthermic exposure during pregnancy.
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Collections - 서울 의과대학 > 서울 해부·세포생물학교실 > 1. Journal Articles
- 서울 예술·체육대학 > 서울 체육학과 > 1. Journal Articles
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