Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndromeopen access
- Authors
- Jo, Heyon-Na; Kim, Jieun; Hwang, Seong-Yeon; Seo, Jun-Won; Kim, Da Young; Yun, Na-Ra; Kim, Dong-Min; Kim, Choon-Mee; Jung, Sook In; Kim, Uh Jin; Kim, Seong Eun; Kim, Hyunah; Kim, Eu Suk; Hur, Jian; Kim, Young Keun; Jeong, Hye Won; Heo, Jung Yeon; Jung, Dong Sik; Lee, Hyungdon; Park, Sun Hee; Kwak, Yee Gyung; Lee, Sujin; Lim, Seungjin
- Issue Date
- May-2022
- Publisher
- MDPI
- Keywords
- Mortality; SFTS phlebovirus; Viral RNA load
- Citation
- Viruses, v.14, no.5, pp.1 - 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Viruses
- Volume
- 14
- Number
- 5
- Start Page
- 1
- End Page
- 11
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/170236
- DOI
- 10.3390/v14050881
- ISSN
- 1999-4915
- Abstract
- The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers <10,000 in the survival and non-survival groups, respectively (p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.
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