Metabolic Score for Insulin Resistance Is Inversely Related to Incident Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Diseaseopen access
- Authors
- Lee, Jun-Hyuk; Kwon, Yu-Jin; Park, Kyongmin; Lee, Hye Sun; Park, Hoon-Ki; Han, Jee Hye; Ahn, Sang Bong
- Issue Date
- Aug-2022
- Publisher
- MDPI
- Keywords
- liver fibrosis; insulin resistance; incidence; Korean; non-alcoholic fatty liver disease
- Citation
- NUTRIENTS, v.14, no.15, pp.1 - 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRIENTS
- Volume
- 14
- Number
- 15
- Start Page
- 1
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171525
- DOI
- 10.3390/nu14153039
- ISSN
- 2072-6643
- Abstract
- We determined the relationships between metabolic score for IR (METS-IR), triglyceride-glucose (TyG) index, and homeostatic model assessment for IR (HOMA-IR) and incident advanced liver fibrosis (ALF) and assessed the abilities of the three IR indicators to predict ALF in patients with non-alcoholic fatty liver disease (NAFLD) in adults with NAFLD who were aged 40-69 years old. Among 2218 participants with NAFLD at baseline, the areas under the receiver operating characteristic curve for predicting ALF of the METS-IR was 0.744 (0.679-0.810), significantly higher than that of TyG index (0.644 (0.569-0.720)) or that of HOMA-IR (0.633 (0.556-0.710)). Among 1368 patients with NAFLD and without ALF at baseline, 260 (19.0%) patients with NAFLD progressed to ALF during the 16-year follow-up period. Multivariable Cox proportional hazard regression analysis revealed that the adjusted hazard ratio (95% confidence interval) for incident ALF in the highest tertiles of METS-IR, TyG index, and HOMA-IR compared with the lowest tertile of each IR indicator were 0.5 (0.36-0.91), 0.7 (0.49-1.00), and 1.01 (0.71-1.42), respectively. METS-IR was inversely associated with ALF in patients with NAFLD, which cautiously suggests that the risk of ALF may need to be evaluated when metabolic parameters improve in individuals with NAFLD.
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