성인형 스틸병 환자의 골수소견과 골수에서의 TNF-α와 IL-18의 발현Bone Marrow Findings, and TNF-α, IL-18 Expression in Bone Marrow of dult Onset Still’s Disease Patients
- Other Titles
- Bone Marrow Findings, and TNF-α, IL-18 Expression in Bone Marrow of dult Onset Still’s Disease Patients
- Authors
- 정경희; 김혜영; 손창남; 김주형; 김원준; 이경아; 박호현; 이웅수; 유대현
- Issue Date
- Jun-2009
- Publisher
- 대한류마티스학회
- Keywords
- Adult onset Still’s disease; Tumor necrosis factor-alpha; Interleukin-18; Bone marrow
- Citation
- 대한류마티스학회지, v.16, no.2, pp.87 - 94
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 16
- Number
- 2
- Start Page
- 87
- End Page
- 94
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171662
- DOI
- 10.4078/jkra.2009.16.2.87
- ISSN
- 2093-940X
- Abstract
- Objective: Inflammatory cytokines may play important roles in the pathogenesis of adult onset Still’s disease. The enhanced expression of IL-18 was reported in the bone marrow of a Japanese systemic onset juvenile rheumatoid arthritis patient but not in the other organs. To date, there are very few studies relating the bone marrow and AOSD. This study examined the bone marrow findings as well as TNF-α and IL-18 expression in the bone marrow of AOSD patients.
Methods: A retrospective study was performed on 15 AOSD patients who had undergone a bone marrow examination at a university hospital. The clinical and laboratory findings, as well as the bone marrow findings, were analyzed. Immunohistochemistry of IL-18 and TNF-α in bone marrow was performed.
Results: The bone marrow cellularity and myeloid/erythroid cell ratio showed no correlation with the clinical and laboratory findings. TNF-α was expressed at 0.8∼9.8% and IL-18 was expressed at 0.4∼9.8% of bone marrow cells. Cytokine expression was not associated with the clinical patterns of AOSD. The platelet count correlated with the bone marrow TNF-α expression but TNF-α did not correlate with IL-18 expression.
Conclusion: TNF-α and IL-18 expression in bone marrow were observed in some AOSD patients but there was no correlation with the other clinical and laboratory findings except for the platelet count.
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