T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
DC Field | Value | Language |
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dc.contributor.author | Kumar, Priti | - |
dc.contributor.author | Ban, Hong-Seok | - |
dc.contributor.author | Kim, Sang-Soo | - |
dc.contributor.author | Wu, Haoquan | - |
dc.contributor.author | Pearson, Todd | - |
dc.contributor.author | Greiner, Dale L. | - |
dc.contributor.author | Laouar, Amale | - |
dc.contributor.author | Yao, Jiahong | - |
dc.contributor.author | Haridas, Viraga | - |
dc.contributor.author | Habiro, Katsuyoshi | - |
dc.contributor.author | Yang, Yong-Guang | - |
dc.contributor.author | Jeong, Ji-Hoon | - |
dc.contributor.author | Lee, Kuen-Yong | - |
dc.contributor.author | Kim, Yong-Hee | - |
dc.contributor.author | Kim, Sung Wan | - |
dc.contributor.author | Peipp, Matthias | - |
dc.contributor.author | Fey, Georg H. | - |
dc.contributor.author | Manjunath, N. | - |
dc.contributor.author | Shultz, Leonard D. | - |
dc.contributor.author | Lee, Sang-Kyung | - |
dc.contributor.author | Shankar, Premlata | - |
dc.date.accessioned | 2022-10-07T10:10:14Z | - |
dc.date.available | 2022-10-07T10:10:14Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171930 | - |
dc.description.abstract | Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection. A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD79R) for T cell-specific siRNA delivery in NOD/SCIDIL2r gamma(-/-) mice reconstituted with human lymphocytes (Hu-PBL) or CD34(+) hematopoietic stem cells (Hu-HSC). In HIV-infected Hu-PBL mice, treatment with anti-CCR5 (viral coreceptor) and antiviral siRNAs complexed to scFvCD7-9R controlled viral replication and prevented the disease-associated CD4 T cell loss. This treatment also suppressed endogenous virus and restored CD4 T cell counts in mice reconstituted with HIV+ peripheral blood mononuclear cells. Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kuen-Yong | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hee | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Kyung | - |
dc.identifier.doi | 10.1016/j.cell.2008.06.034 | - |
dc.identifier.scopusid | 2-s2.0-49549117077 | - |
dc.identifier.wosid | 000258665800012 | - |
dc.identifier.bibliographicCitation | CELL, v.134, no.4, pp.577 - 586 | - |
dc.relation.isPartOf | CELL | - |
dc.citation.title | CELL | - |
dc.citation.volume | 134 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 577 | - |
dc.citation.endPage | 586 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | SMALL INTERFERING RNA | - |
dc.subject.keywordPlus | LENTIVIRAL VECTOR | - |
dc.subject.keywordPlus | CHAIN IMMUNOTOXIN | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | HU MICE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | C-MYB | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | CELLIMMUNO | - |
dc.subject.keywordAuthor | HUMDISEASE | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0092867408008210?via%3Dihub | - |
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