알파-리포산이 비만형 제2형 당뇨병 백서 모델의 단백뇨 및 신장 TGFβ 발현에 미치는 효과

Abstract

Pair-fed group: 4.977 ± 0.339 mg/mgCr, P < 0.001; renal TGFβ protein expression, Control group: 7.09 ± 0.17 RU, ALA group: 4.14 ± 0.26 RU, Pair-fed group: 7.00 ± 0.29 RU, P < 0.001). In the ALA group at 35 weeks of age, urinary protein excretion and renal TGFβ protein expression were positively related in the Control, ALA and Pair-fed groups (Control group, r = 0.847, P = 0.002; ALA group, r = 0.954, P < 0.001; Pair-fed group, r = 0.858, P = 0.002). TGFβ staining in glomeruli was observed in all groups but was decreased in the ALA group at 35 weeks of age. Conclusion: These results suggest that ALA may prevent the increase of food intake, body weight, blood glucose, urinary protein excretion and renal TGFβ protein expression in obese type 2 diabetic rat model. The effect of ALA on diabetic nephropathy presented as proteinuria and renal TGFβ expression in diabetic patients needs to be further clarified. (J Kor Diabetes Assoc 32:21~29, 2008)