가토 상악동에 이식된 β-TCP의 골치유에 관한 실험적 연구THE EXPERIMENTAL STUDY OF THE BONE REGENERATION ON RABBIT MAXILLARY SINUS GRAFTING WITH β-TCP
- Other Titles
- THE EXPERIMENTAL STUDY OF THE BONE REGENERATION ON RABBIT MAXILLARY SINUS GRAFTING WITH β-TCP
- Authors
- 박정하; 황경균; 박창주; 최용수; 마평수; 백승삼; 심광섭
- Issue Date
- Apr-2006
- Publisher
- 대한구강악안면외과학회
- Keywords
- β-TCP; Rabbit; Maxillary sinus
- Citation
- 대한구강악안면외과학회지, v.32, no.2, pp.107 - 116
- Indexed
- KCI
- Journal Title
- 대한구강악안면외과학회지
- Volume
- 32
- Number
- 2
- Start Page
- 107
- End Page
- 116
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172497
- ISSN
- 2234-7550
- Abstract
- Purpose:Maxillay sinus grafting is an effective treatment procedure to improve bone height in the posterior maxillar area for implant installation. Beta-tricalciumphosphate(β-TCP) was introduced to be grafting substitute material, providing a reasonable bio-degradation time, no need for harvesting procedure. The purpose of this study is to evaluate bone healing & regeneration phase using histomorphometric and immunohistochemical analysis. Material & Methods:Sixteen rabbits were divided into 4 groups. Bi-lateral maxillary sinus membranes were elevated at each rabbits, β-TCP was augmented in left sinus, autogenous bone was augmented in right sinus. The rabbits were sacrificed at 2, 4, 8 and 12 weeks. We investigated the bone regeneration & growth factor expression. Results: 1. The mean new bone volume formation was 28.99±6.55%, 49.54±5.47%, 69.09±8.90% in autogenous grafted area, and 22.86±5.56%, 24.00 ±4.09%, 34.11±3.37% in β-TCP area at 4, 8, 12 weeks. Therefore, new bone formation in autogenous bone was significantly higher than β- TCP (p<0.05). 2. The BMP 2/4 expression in autogenous bone grafted area was higher at 4, 8 weeks. 3. There was no difference in expression pattern of BMP-7/PDGF/VEGF during grafted bone regeneration. Conclusion:The authors we conclude that the autogenous bone graft was faster than β-TCP in bone regeneration, and the BMP 2/4 were more important in graft bone regeneration.
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