Erythrocyte alpha-linolenic acid is associated with the risk for mild dementia in Korean elderly
DC Field | Value | Language |
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dc.contributor.author | Kim, Malgeunsinae | - |
dc.contributor.author | Nam, Jung Hyun | - |
dc.contributor.author | Oh, Dong Hoon | - |
dc.contributor.author | Park, Yongsoon | - |
dc.date.accessioned | 2022-12-20T11:05:18Z | - |
dc.date.available | 2022-12-20T11:05:18Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/173479 | - |
dc.description.abstract | n-3 polyunsaturated fatty acids (PUFA) play an important role in brain development and function, but there is conflicting evidence between the relationship of n-3 PUFA and dementia in the elderly. The purpose of the present study was to test the hypothesis that n-3 PUFA content of erythrocytes is associated with mild dementia in elderly Koreans. Fifty-seven elderly (age 65 years) patients (19 male, 38 female) were recruited, and indicators of dementia (intake, erythrocyte fatty acid composition, and Mini-Mental Status Examination-Korean Version [MMSE-K]) were evaluated. Patients were divided into groups based on their MMSE-K score: normal control group (score >21 [n = 24]) and deficit group (score 21 [n = 33]). Multivariate-adjusted regression analysis showed that a higher level of alpha-linolenic acid (ALA; 18:3n-3) significantly decreased the risk of mild dementia after adjusting for age, sex, and height. MMSE-K score was also significantly and positively associated with erythrocyte ALA and total n-3 PUFA. However, erythrocyte levels of docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid (20:5n-3) were not significantly related with the risk of mild dementia and MMSE-K score. Dietary intake was also not significantly associated with the risk of mild dementia and MMSE-K score after adjusting for age, sex, height, and energy intake. In conclusion, ALA derived from plant sources of n-3 PUFA, but not eicosapentaenoic acid and docosahexaenoic acid from fish, decreased the risk for mild dementia among the Korean elderly. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Erythrocyte alpha-linolenic acid is associated with the risk for mild dementia in Korean elderly | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1016/j.nutres.2010.10.005 | - |
dc.identifier.scopusid | 2-s2.0-78649820617 | - |
dc.identifier.wosid | 000285405900003 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, v.30, no.11, pp.756 - 761 | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.citation.title | NUTRITION RESEARCH | - |
dc.citation.volume | 30 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 756 | - |
dc.citation.endPage | 761 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | N-3 FATTY-ACIDS | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | ALZHEIMER-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE DECLINE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | OLDER PERSONS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | FISH | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | n-3 polyunsaturated fatty acids | - |
dc.subject.keywordAuthor | alpha-Linolenic acid | - |
dc.subject.keywordAuthor | Erythrocyte | - |
dc.subject.keywordAuthor | Dementia | - |
dc.subject.keywordAuthor | Elderly | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S027153171000206X?via%3Dihub | - |
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