The timing of intra-coronary infusion of G-CSF mobilized peripheral blood stem cells influences cardiac function and in-stent restenosis in patients with myocardial infarction
- Authors
- Kim, Kyung-Soo; Jin, Jiyong; Lee, Young-Yiul; Choi, Sung-Il; Shin, Jin-Ho; Kim, Jeong-Hyun; Lim, Heon-Gil; Lee, Bang-Hun; Choi, Yun-Young; Lee, Seok-Mo; Koh, Hyun-Chul
- Issue Date
- Aug-2010
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Myocardial infarction; Peripheral blood stem cell; Granulocyte colony stimulating factor; In-stent restenosis
- Citation
- INTERNATIONAL JOURNAL OF CARDIOLOGY, v.143, no.2, pp.202 - 205
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF CARDIOLOGY
- Volume
- 143
- Number
- 2
- Start Page
- 202
- End Page
- 205
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174392
- DOI
- 10.1016/j.ijcard.2008.11.192
- ISSN
- 0167-5273
- Abstract
- We hypothesized that delaying the timing of intra-coronary infusion of G-CSF mobilized stem cell until at least 4 weeks after coronary stenting should avoid the stimulation of vascular smooth muscle cells during the early active cellular proliferative phase, thus decreases in-stent restenosis while preserving the beneficial effect of stem cell therapy on cardiac function in patients with myocardial infarction (MI). 25 patients with ST-elevation myocardial infarction (STEMI) treated with stenting were enrolled in this pilot study. The ages of MI at the time of cell treatment were from 1 month to 59 months. At 6 months follow-up, the left ventricular ejection fraction (LVEF) increased from 32% to 37.7% and the stress thallium perfusion defect decreased from 31.4% to 28.1%. Cell treatment-related complications such as arrhythmias were not observed. 9 patients who underwent cell treatment less than 3 months after coronary stenting were evaluated for in-stent restenosis; it was found in only 1 patient. This pilot study shows that delayed more than 4 weeks after coronary stenting but less than 3 months after MI, intra-coronary infusion of G-CSF mobilized PBSCs may improve cardiac function without triggering in-stent restenosis.
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