피부근육염/다발근육염에서 발생한 자발 종격동기종의 임상적 의미Clinicial Significance of Spontaneous Pneumomediastinum in Dermatomyositis/Polymyositis
- Other Titles
- Clinicial Significance of Spontaneous Pneumomediastinum in Dermatomyositis/Polymyositis
- Authors
- 김진주; 김담; 김은경; 손일웅; 정경희; 최찬범; 성윤경; 전재범; 엄완식; 김태환; 배상철; 유대현
- Issue Date
- Jun-2010
- Publisher
- 대한류마티스학회
- Keywords
- Pneumomediastinum; Dermatomyositis/polymyositis; Interstitial lung disease; Prognosis
- Citation
- 대한류마티스학회지, v.17, no.2, pp.143 - 152
- Indexed
- KCI
- Journal Title
- 대한류마티스학회지
- Volume
- 17
- Number
- 2
- Start Page
- 143
- End Page
- 152
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174541
- DOI
- 10.4078/jkra.2010.17.2.143
- ISSN
- 2093-940X
- Abstract
- Objective: Pneumomediastinum (PnM), a rare complication of dermatomyositis and polymyositis (DM/PM), is sporadic and has an unclear pathogenesis. PnM is almost always associated with interstitial lung disease (ILD), and is a poor prognostic factor in inflammatory myositis patients. We studied the prevalence of PnM in Korean DM/PM and its clinical significance.
Methods: We retrospectively studied the medical records of 161 patients diagnosed with DM/PM meeting Bohan-Peter’s criteria at Hanyang University Hospital for Rheumatic Diseases from 1995 to 2010. We collected following findings; demographic data, diagnosis, lung involvement, cause of death, and duration from diagnosis to death.
Results: One hundred nineteen patients (73.9%) were DM and 42 patients (26.1%) were PM. Eighty three patients (51.6%) developed ILD at diagnosis or during follow up. Eighteen patients (11.2%) died because of ILD aggravation, infection, or malignancy. The mean duration from diagnosis to death was 11.5 months, with 10 patients (6.2%) dying from from ILD aggravation but none with spontaneous PnM. 6 patients (3.7%) presented with PnM, and it was associated with ILD worsening in all cases. PnM resolved with O2 inhalation, corticosteroids, and/or immunosuppressive agents after 11 weeks (mean) of therapy Conclusion: PnM is rare but associates with DM and aggravation of ILD. PnM does not usually cause fatalities and can be cured by appropriate therapy.
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