A Case of Pure Red Cell Aplasia Associated with Angioimmunoblastic T-cell Lymphomaopen access
- Authors
- Choi, Jung-Hye; Oh, Young-Ha; Park, Ile-Kyu
- Issue Date
- Jun-2010
- Publisher
- KOREAN CANCER ASSOCIATION
- Keywords
- Red-cell aplasia; Pure; Lymphoma; T-cell
- Citation
- CANCER RESEARCH AND TREATMENT, v.42, no.2, pp.115 - 117
- Indexed
- SCIE
KCI
- Journal Title
- CANCER RESEARCH AND TREATMENT
- Volume
- 42
- Number
- 2
- Start Page
- 115
- End Page
- 117
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174901
- DOI
- 10.4143/crt.2010.42.2.115
- ISSN
- 1598-2998
- Abstract
- Pure red cell aplasia is a bone marrow failure characterized by a progressive normocytic anemia and reticulocytopenia without leucopenia and thrombocytopenia. It is associated with various hematologic diseases. However, pure red cell aplasia with angioimmunoblastic T cell lymphoma has rarely been reported. Here we describe a 43-year-old woman with pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma. She had severe anemia (hemoglobin 6.9 g/dL) and a low reticulocyte count (0.2%). Direct and indirect Coombs' tests were positive. A CT scan of the abdomen revealed marked hepatosplenomegaly and small multiple lymphadenopathies. A bone marrow biopsy revealed focal infiltration of abnormal lymphoid cells and absence of red cell precursors. Splenic biopsy was compatible with angioimmunoblastic T-cell lymphoma. Ultimately, diagnosis of pure red cell aplasia associated with angioimmunoblastic T-cell lymphoma was made. After initiating CHOP therapy, the patient achieved complete remission, which was accompanied, shortly thereafter, by a rise in hemoglobin levels which finally returned to normal.
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