Characteristics of Plasmid-Mediated Quinolone Resistance Genes in Extended-Spectrum Cephalosporin-Resistant Isolates of Klebsiella pneumoniae and Escherichia coli in Korea
- Authors
- Seo, Mi-Ran; Park, Yoon Soo; Pai, Hyunjoo
- Issue Date
- Apr-2010
- Publisher
- KARGER
- Keywords
- Enterobacteriaceae; Extended-spectrum cephalosporins; Escherichia coli; Klebsiella pneumoniae; beta-Lactamase; Plasmid-mediated quinolone resistance; Quinolone resistance
- Citation
- CHEMOTHERAPY, v.56, no.1, pp.46 - 53
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMOTHERAPY
- Volume
- 56
- Number
- 1
- Start Page
- 46
- End Page
- 53
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175154
- DOI
- 10.1159/000290972
- ISSN
- 0009-3157
- Abstract
- Background: Quinolone resistance is frequently associated with extended-spectrum cephalosporin resistance in Enterobacteriaceae. Methods: The characteristics of plasmid-mediated quinolone resistance (PMQR) genes [qnr genes, aac(6')-lb-cr and qepA] in clinical isolates of Klebsiella pneumoniae and Escherichia coli resistant to extended-spectrum cephalosporin were studied. Results: 5 and 4 of 95 E. coli isolates but 46 (86/187) and 6% (12/187) of K. pneumoniae had qnr and aac(6')-lb-cr,respectively, and 8 K. pneumoniae contained both genes. qepA was not identified. qnrB, especially qnrB4, was the predominant qnr subtype in K. pneumoniae [94 (88 qnrB of 94 qnr) and 88% (77 qnrB4 of 88 qnrB), respectively], and presence of qnrB4 was closely related with DHA-1 beta-lactamase (99%). However, K. pneumoniae isolates with qnrB4 and bla(DHA-1) were clonally diverse. beta-Lactamases produced by PMQR-containing isolates were variable: CMY-1, CTX-M-14, CTX-M-15, DHA-1, OXA type, SHV-2a, and SHV-12. Conclusion: PMQR genes are widely distributed among clinical isolates of K. pneumoniae, and qnrB4 associated with bla(DHA-1) was the most common PMQR gene in Korea.
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