Improved treatment outcome of primary mediastinal large B-cell lymphoma after introduction of rituximab in Korean patients
- Authors
- Ahn, Hee Kyung; Kim, Seok Jin; Yun, Jina; Yi, Jun Ho; Kim, Jung-Hoon; Won, Young-Woong; Kim, Kihyun; Ko, Young Hyeh; Kim, Won Seog
- Issue Date
- Apr-2010
- Publisher
- SPRINGER TOKYO
- Keywords
- Mediastinal large B-cell lymphoma; Prognosis; Rituximab
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v.91, no.3, pp.456 - 463
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Volume
- 91
- Number
- 3
- Start Page
- 456
- End Page
- 463
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175216
- DOI
- 10.1007/s12185-010-0536-6
- ISSN
- 0925-5710
- Abstract
- The addition of rituximab to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) improved the outcome of patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab (R-CHOP) is still not determined in primary mediastinal large B-cell lymphoma (PMBCL), a subtype of DLBCL, especially in Asian patients. Thus, we analyzed the treatment outcome of PMBCL patients (n = 21) treated with R-CHOP and compared it with the historical group treated with CHOP (n = 14). The rate of complete response for R-CHOP was higher than that of CHOP (17/21, 81.0% vs. 8/14, 57.2%), although the difference was not statistically significant (P = 0.151). The number of patients with disease progression or relapse was higher in the CHOP group (6/14, 42.9%) than the R-CHOP group (2/21, 9.5%). Thus, patients treated with R-CHOP had higher 2-year progression-free survival (79.0%) than those treated with CHOP (50.0%, P = 0.043). Although the 2-year overall survival of the R-CHOP was also superior to that of the CHOP group (82.7% vs. 57.1%), this survival benefit did not reach statistical significance (P = 0.081). In conclusion, our comparison suggests that R-CHOP may increase response and reduce relapse resulting in prolongation of progression-free survival of patients with PMBCL.
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