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Clinical and radiologic evaluation of cytomegalovirus-induced thrombocytopenia in infants between 1 and 6 months of ageopen accessClinical and radiologic evaluation of cytomegalovirus-induced thrombocytopenia in infants between 1 and 6 months of age

Other Titles
Clinical and radiologic evaluation of cytomegalovirus-induced thrombocytopenia in infants between 1 and 6 months of age
Authors
강준원김기나김선영김희진박은실김재영이영호
Issue Date
Mar-2010
Publisher
대한혈액학회
Keywords
Thrombocytopenia; Cytomegalovirus; Infant
Citation
Blood Research, v.45, no.1, pp.29 - 35
Indexed
KCI
Journal Title
Blood Research
Volume
45
Number
1
Start Page
29
End Page
35
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175282
DOI
10.5045/kjh.2010.45.1.29
ISSN
2287-979X
Abstract
Background Up to 90% of neonates with congenital or perinatal cytomegalovirus (CMV) infection are asymptomatic, and little is known about CMV-associated thrombocytopenia after the neonatal period. We investigated the clinical findings of a series of infants diagnosed with CMV infection and thrombocytopenia. Methods From July 2005 to July 2008, infants aged younger than 6 months with thrombocytopenia were screened for CMV infection, using CMV IgM. Those who were positive for CMV IgM were then tested for CMV IgG via polymerase chain reaction (PCR) for CMV and CMV pp65 Ag and urine culture. Brain magnetic resonance imaging (MRI) and otologic and ophthalmologic evaluations were also performed. Results Twenty-one patients aged between 1 and 6 months (11 boys and 10 girls) were admitted and tested for CMV infection. Six patients (28.6%) were positive for CMV IgM; these were also positive for CMV IgG, CMV PCR, and urine culture, and 4 were also positive for CMV pp65 Ag. The median platelet count at admission was 6,500 /mL (range, 2,000-105,000 /mL). One patient (16.7%) was diagnosed with Evans syndrome and had calcifications on brain MRI. One patient had unilateral sensorineural hearing loss. Conclusion Thrombocytopenia can be the main clinical manifestation of otherwise asymptomatic CMV infection after the neonatal period, and close follow-up of neurodevelopmental sequelae is needed.
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