Icodextrin improves the serum potassium profile with the enhancement of nutritional status in continuous ambulatory peritoneal dialysis patientsopen access
- Authors
- Yi, Joo-Hark; Park, Jae-Il; Choi, Hoon-Young; Lee, Ho-Yung; Han, Sang Woong; Kim, Ho-Jung
- Issue Date
- Dec-2009
- Publisher
- Korean Society of Electrolyte and Blood Pressure Research
- Keywords
- Hypokalemia; Icodextrin; Nutritional status; Peritoneal dialysis; Serum albumin
- Citation
- Electrolyte and Blood Pressure, v.7, no.2, pp.79 - 86
- Indexed
- SCOPUS
KCI
OTHER
- Journal Title
- Electrolyte and Blood Pressure
- Volume
- 7
- Number
- 2
- Start Page
- 79
- End Page
- 86
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175710
- DOI
- 10.5049/EBP.2009.7.2.79
- ISSN
- 1738-5997
- Abstract
- The impact of glucose-free icodextrin (ID) for overnight dwell as compared to conventional glucose-containing dialysate (GD) on potassium (K+) metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients has not yet been investigated. Serum K+ in a total of 255 stable patients (116 on GD and 139 on ID) on CAPD for more than 6 months and in 139 patients on ID before and after ID use (Pre-ID and Post-ID) were observed along with nutritional markers in a 2-year study period (Jan. 2006 to Dec. 2007). The prevalence of hypokalemia was similar between patients on GD and ID (16.7% vs 17.3%), but was lower on Post-ID than Pre-ID (17.3% vs 20.5%) without statistic significance. The mean serum K+ level was higher on ID than on GD (P<0.05) as well as Post-ID than Pre-ID (P<0.001). In the multivariate analysis, serum K+ levels were positively correlated with serum albumin, and creatinine in all patients (P<0.05), and ID-use in younger patients (age≤56, P<0.001). Serum albumin, creatinine, total CO 2, and body mass index were significantly higher on Post-ID than Pre-ID. Icodextrin dialysate for chronic overnight dwell could increase serum K+ levels and lower the prevalence of hypokalemia compared to conventional glucose-containing dialysate. The improved chronic K+ balance in CAPD patients on icodextrin could be related to enhanced nutritional status rather than its impact on acute intracellular K+ redistribution.
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