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Depressive Symptoms and Brain Metabolite Alterations in Subjects at Ultra-high Risk for Psychosis: A Preliminary Studyopen access

Authors
Byun, Min SooChoi, Jung-SeokYoo, So YoungKang, Do-HyungChoi, Chi-HoonJang, Dong PyoJung, Wi HoonJung, Myung HunJang, Joon HwanLee, Jong-MinKwon, Jun Soo
Issue Date
Dec-2009
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Depression; Magnetic resonance spectroscopy; Schizophrenia; Ultra-high risk
Citation
PSYCHIATRY INVESTIGATION, v.6, no.4, pp.264 - 271
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
PSYCHIATRY INVESTIGATION
Volume
6
Number
4
Start Page
264
End Page
271
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175723
DOI
10.4306/pi.2009.6.4.264
ISSN
1738-3684
Abstract
Objective Recent neuroimaging studies have suggested that brain changes occur in subjects at ultra-high risk (UHR) for psychosis while experiencing prodromal symptoms, among which depression may increase the risk of developing a psychotic disorder. The goal of this study is to examine brain metabolite levels in the anterior cingulate cortex, the left dorsolateral prefrontal cortex and the left thalamus in subjects at UHR for psychosis and to compare brain metabolite levels between the UHR subjects with comorbid major depressive disorder and healthy controls. Methods Proton magnetic resonance spectroscopy was used to examine brain metabolite levels. Twenty UHR subjects and 20 age- and intelligence quotient (IQ)-matched healthy controls were included in this study. Results Overall, no significant differences were observed in any metabolite between the UHR and healthy control group. However, UHR subjects with major depressive disorder showed significantly higher myo-inositol (Ins) levels in the left thalamus, compared to the healthy control. Conclusion Our results demonstrate that increased thalamic Ins level is associated with prodromal depressive symptoms. Further longitudinal follow-up studies with larger UHR sample sizes are required to investigate the function of Ins concentrations as a biomarker of vulnerability to psychosis.
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