Catechin-loaded calcium pectinate microparticles reinforced with liposome and hydroxypropylmethylcellulose: Optimization and in vivo antioxidant activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji-Soo | - |
dc.contributor.author | Kim, Hye Won | - |
dc.contributor.author | Chung, Donghwa | - |
dc.contributor.author | Lee, Hyeon Gyu | - |
dc.date.accessioned | 2022-12-20T19:59:42Z | - |
dc.date.available | 2022-12-20T19:59:42Z | - |
dc.date.created | 2022-08-26 | - |
dc.date.issued | 2009-12 | - |
dc.identifier.issn | 0268-005X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175781 | - |
dc.description.abstract | The preparation conditions of Ca-pectinate microparticles reinforced with liposome and hydroxypropyl methylcellulose (HPMC), including CaCl2 concentration (X-1), HPMC concentration (X-2), and hardening time (X-3), were optimized for the sustained-release of catechin into simulated gastric and intestinal fluids using response surface methodology. The optimized values of X-1, X-2, and X-3 were found to be 5.20%, 0.08%, and 12.63 min, respectively. The microparticles prepared according to the optimized conditions released about 50% of the entrapped catechin into simulated gastric fluid during 24-h incubation period, whereas almost complete catechin release was observed in simulated intestinal fluid after 8-h incubation. Antioxidant activity of catechin in rat plasma was more effectively maintained when the catechin-loaded microparticles were fed, compared to the case of feeding free catechin, indicating that the microparticles can protect catechin molecules in the rat model and release them in a sustained manner. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Catechin-loaded calcium pectinate microparticles reinforced with liposome and hydroxypropylmethylcellulose: Optimization and in vivo antioxidant activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyeon Gyu | - |
dc.identifier.doi | 10.1016/j.foodhyd.2009.05.005 | - |
dc.identifier.scopusid | 2-s2.0-70149124721 | - |
dc.identifier.wosid | 000270890200026 | - |
dc.identifier.bibliographicCitation | FOOD HYDROCOLLOIDS, v.23, no.8, pp.2226 - 2233 | - |
dc.relation.isPartOf | FOOD HYDROCOLLOIDS | - |
dc.citation.title | FOOD HYDROCOLLOIDS | - |
dc.citation.volume | 23 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2226 | - |
dc.citation.endPage | 2233 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | GEL BEADS | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | DRUG-RELEASE | - |
dc.subject.keywordPlus | VITRO EVALUATION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ALGINATE | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | ENTRAPMENT | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Catechin | - |
dc.subject.keywordAuthor | Ca-pectinate microparticles | - |
dc.subject.keywordAuthor | Response surface methodology | - |
dc.subject.keywordAuthor | Antioxidant activity | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0268005X09001052?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.