Catechin-loaded calcium pectinate microparticles reinforced with liposome and hydroxypropylmethylcellulose: Optimization and in vivo antioxidant activity
- Authors
- Lee, Ji-Soo; Kim, Hye Won; Chung, Donghwa; Lee, Hyeon Gyu
- Issue Date
- Dec-2009
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Catechin; Ca-pectinate microparticles; Response surface methodology; Antioxidant activity
- Citation
- FOOD HYDROCOLLOIDS, v.23, no.8, pp.2226 - 2233
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD HYDROCOLLOIDS
- Volume
- 23
- Number
- 8
- Start Page
- 2226
- End Page
- 2233
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175781
- DOI
- 10.1016/j.foodhyd.2009.05.005
- ISSN
- 0268-005X
- Abstract
- The preparation conditions of Ca-pectinate microparticles reinforced with liposome and hydroxypropyl methylcellulose (HPMC), including CaCl2 concentration (X-1), HPMC concentration (X-2), and hardening time (X-3), were optimized for the sustained-release of catechin into simulated gastric and intestinal fluids using response surface methodology. The optimized values of X-1, X-2, and X-3 were found to be 5.20%, 0.08%, and 12.63 min, respectively. The microparticles prepared according to the optimized conditions released about 50% of the entrapped catechin into simulated gastric fluid during 24-h incubation period, whereas almost complete catechin release was observed in simulated intestinal fluid after 8-h incubation. Antioxidant activity of catechin in rat plasma was more effectively maintained when the catechin-loaded microparticles were fed, compared to the case of feeding free catechin, indicating that the microparticles can protect catechin molecules in the rat model and release them in a sustained manner.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 생활과학대학 > 서울 식품영양학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175781)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.