Investigation of Cell-Matrix Interactions Using a FRET Technique
- Authors
- Shahbuddin, Munira B.; Park, Honghyun; Lee, Jae Won; Park, Soyeon; Lee, Kuen Yong
- Issue Date
- Aug-2009
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- RGD peptide; Alginate hydrogel; Ligand organization; FRET; Tissue engineering
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.30, no.8, pp.1817 - 1820
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 30
- Number
- 8
- Start Page
- 1817
- End Page
- 1820
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176427
- DOI
- 10.5012/bkcs.2009.30.8.1817
- ISSN
- 0253-2964
- Abstract
- Controlling cell-matrix interactions is critical in regulating cell phenotypes for tissue engineering applications. Cellular adhesion to synthetic extracellular matrices (ECMs) call be enhanced by introduction of adhesion ligands to the matrices. We tested the hypothesis that biophysical cues such as ligand organization in synthetic ECMs play an important role in modulating cell responses to the microenvironment. To investigate and monitor cell-matrix interactions, we used a fluorescence resonance energy transfer (FRET) technique with cell-interactive polymers generated by conjugating a peptide with the sequence of arginine-glycine-aspartic acid (RGD) to alginate hydrogels.
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