Effects of alpha-lipoic acid on transforming growth factor beta 1-p38 mitogen-activated protein diabetic kinase-fibronectin pathway in nephropathy
- Authors
- Lee, Seong Jin; Kang, Jun Goo; Ryu, Ohk Hyun; Kim, Chul Sik; Ihm, Sung-Hee; Choi, Moon Gi; Yoo, Hyung Joon; Kim, Dong-Sun; Kim, Tae Wha
- Issue Date
- May-2009
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Citation
- METABOLISM-CLINICAL AND EXPERIMENTAL, v.58, no.5, pp.616 - 623
- Indexed
- SCIE
SCOPUS
- Journal Title
- METABOLISM-CLINICAL AND EXPERIMENTAL
- Volume
- 58
- Number
- 5
- Start Page
- 616
- End Page
- 623
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176824
- DOI
- 10.1016/j.metabol.2008.12.006
- ISSN
- 0026-0495
- Abstract
- In diabetic nephropathy, transforming growth factor beta 1 (TGF beta 1) is related to p38 mitogen-activated protein kinase (MAPK) that induces production of fibronectin in mesangial cells. We investigated the effects of a-lipoic acid (ALA), a potent antioxidant, on proteinuria and TGF beta 1-p38 MAPK-fibroncetin pathway in diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. After ALA treatment for 5 weeks in OLETF rats at 30 weeks of age, plasma malondialdehyde, Urinary protein excretion, renal cortical TGF beta 1, and fibronectin protein levels were decreased; and Urinary protein excretion was positively correlated with renal cortical TGF beta 1 and fibronectin protein levels. Phosphoform but riot total-form levels as welt as fold activations of each protein consisting of p38 MAPK pathway were also attenuated. These results suggest that ALA ameliorates proteinuria by attenuating expressions of TGF beta 1 and fibronectin proteins, and these favorable effects are related to inhibition of phosphorylating activation of p38 MAPK pathway in renal cortex of OLETF rats.
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