gamma-Oryzanol-loaded calcium pectinate microparticles reinforced with chitosan: Optimization and release characteristics
- Authors
- lee, Ji-Soo; Kim, Jong Soo; Lee, Hyeon Gyu
- Issue Date
- May-2009
- Publisher
- ELSEVIER
- Keywords
- gamma-Oryzanol; Ca pectinate microparticles; Chitosan; Entrapment efficiency; Response surface methodology
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.70, no.2, pp.213 - 217
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 70
- Number
- 2
- Start Page
- 213
- End Page
- 217
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/176862
- DOI
- 10.1016/j.colsurfb.2008.12.028
- ISSN
- 0927-7765
- Abstract
- Response surface methodology was used to optimize microparticle preparation conditions, including the ratio of pectin:gamma-oryzanol (OZ) (X-1), agitation speed (X-2), and the concentration of emulsifier (X-3), for maximal entrapment efficiency (EE) of OZ-loaded Ca pectinate microparticles. The optimized values of X1, X2, and X3 were found to be 2.72:5.28, 1143.5 rpm, and 2.61%, respectively. Experimental results obtained for the optimum formulation agreed favorably with the predicted results, indicating the usefulness of predicting models for EE. In order to evaluate the effect of chitosan-coating and blending on the release pattern of the entrapped OZ from microparticles, chitosan-coated and blended Ca pectinate microparticles were prepared. Release studies revealed that the chitosan treatments, especially the chitosan-coating, were effective ill Suppressing the release in both simulated gastric fluid (SGF) and intestinal fluid (SIF).
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