Diagnostic Benefit of Thyroglobulin Measurement in Fine-Needle Aspiration for Diagnosing Metastatic Cervical Lymph Nodes from Papillary Thyroid Cancer: Correlations with US Featuresopen access
- Authors
- Jeon, Se Jeong; Kim, Eunhee; Park, Jeong Seon; Son, Kyu Ri; Baek, Jung Hwan; Kim, Yoon Suk; Park, Do Joon; Cho, Bo Youn; Na, Dong Gyu
- Issue Date
- Mar-2009
- Publisher
- KOREAN RADIOLOGICAL SOC
- Keywords
- Papillary thyroid cancer; Lymph node metastasis; Ultrasound (US); Fine needle aspiration; Thyroglobulin
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.10, no.2, pp.106 - 111
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 10
- Number
- 2
- Start Page
- 106
- End Page
- 111
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177156
- DOI
- 10.3348/kjr.2009.10.2.106
- ISSN
- 1229-6929
- Abstract
- Objective: Our goals were to determine the added value of fine-needle aspiration biopsy (FNAB)-thyroglobulin (Tg) measurements over FNAB-cytology alone for diagnosing metastatic nodes, and to determine whether the ultrasound features of lymph nodes can be used to identify lymph nodes that may benefit from FNAB-Tg measurement in patients with papillary thyroid cancer.
Materials and Methods: We retrospectively evaluated 76 surgically proven cervical lymph nodes. Twenty-nine patients were awaiting surgery and 18 patients had undergone thyroid surgery for papillary thyroid cancer. Ultrasound-guided FNAB and Tg measurements were performed and the ultrasound features were evaluated.
Results: The accuracies, sensitivities, and specificities of FNAB-cytology, FNAB-Tg, and combined FNAB-Tg/cytology were 90%, 80%, and 100%; 92%, 95%, and 90%; and 93%, 96%, and 90%, respectively. The diagnostic sensitivity of FNAB-Tg for metastatic nodes was significantly higher than that of FNAB-cytology (p = 0.011). Furthermore, combined FNAB-Tg/cytology significantly increased sensitivity (p = 0.002) and accuracy (p = 0.03) as compared with FNAB-cytology.
Conclusion: Combined FNAB-Tg/cytology is significantly more sensitive and accurate at detecting metastatic nodes than FNAB-cytology alone. FNAB-Tg was better at diagnosing metastases in small lymph nodes.
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