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The relative cellular levels of CP2a and CP2b potentiates erythroid cell-specific expression of the alpha-globin gene by regulating the nuclear localization of CP2c

Authors
Chae, Ji HyungKang, Ho ChulKim, Chul Geun
Issue Date
Mar-2009
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Subcellular localization; Protein protein interaction; Transcription factor complex; CP2b; CP2c; alpha-Globin gene
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.380, no.4, pp.813 - 817
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
380
Number
4
Start Page
813
End Page
817
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177201
DOI
10.1016/j.bbrc.2009.01.172
ISSN
0006-291X
Abstract
CP2b activates alpha-globin expression in an erythroid cell-specific manner, through interaction with CP2c and PIAS1. Although CP2a is identical to CP2b except for lacking an exon encoding additional 36 amino acids and has the intrinsic DNA binding and transactivation properties, it does not exert any role in alpha-globin expression. Investigation of subcellular localization of exogenous CP2 proteins revealed that CP2a and CP2b were exclusively localized in the cytosol and nucleus, respectively. The CP2b-specific exon was in charge of the nuclear localization of CP2b. Interestingly, subcellular localization of CP2c was either in the nucleus or cytosol depending on the relative level of CP2a and CP2b although CP2c intrinsically localized in the cytosol in the absence of CP2a/CP2b. Finally, dramatic increment of hemoglobin expression was correlated with nuclear translocation of CP2c during MEL cell differentiation. Our data suggest that CP2b potentiate erythroid cell-specific alpha-globin expression by recruiting CP2c into the nucleus.
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서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
서울 교무처 > 서울 창의융합교육원 > 1. Journal Articles

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Chae, Ji Hyung
서울 부총장(서울) (서울 창의융합교육원)
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