The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population
DC Field | Value | Language |
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dc.contributor.author | 반주연 | - |
dc.contributor.author | 강순아 | - |
dc.contributor.author | 정경희 | - |
dc.contributor.author | 김학재 | - |
dc.contributor.author | 엄윤경 | - |
dc.contributor.author | 김수강 | - |
dc.contributor.author | 임성빈 | - |
dc.contributor.author | 조봉근 | - |
dc.contributor.author | 홍승재 | - |
dc.contributor.author | 성연희 | - |
dc.contributor.author | 고인송 | - |
dc.contributor.author | 정주호 | - |
dc.date.accessioned | 2022-12-21T00:03:30Z | - |
dc.date.available | 2022-12-21T00:03:30Z | - |
dc.date.created | 2022-09-19 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1976-1457 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177546 | - |
dc.description.abstract | Pre-B-cell leukemia transcription factor 1 (PBX1), which is located on chromosome 1q23, was recently reported to be associated with type 2 diabetes mellitus. We examined whether single nucleotide polymorphisms (SNPs) of the PBX1 gene are associated with overweight/obesity in a Korean population. We genotyped 66 SNPs in the PBX1 gene and investigated their association with clinical phenotypes found in 214 overweight/obese subjects and 160 control subjects using the Affymetrix Targeted Genotyping chip array. Seven SNPs (g.+75186C>T, g.+78350C>A, g.+80646C>T, g.+138004C>T, g.+185219G>A, g.+191272A>C, and g.+265317T>A) were associated with the risk of obesity in three models (codominant, dominant, and recessive) (P=0.007-0.05). Haplotype 1 (CAC) and 3 (TAC) of block 3 and haplotype 2 (GGAAT) of block 10 were also strongly associated with the risk of obesity. In the control group, subjects that had homozygote for the major allele for both g.+185219G>A and g.+191272A>C showed lower high density lipoprotein-cholesterol (HDL-C) level compared to those possessing the minor allele, suggesting that the association between the homozygote for the major allele for both g.+185219G>A and g.+191272A>C and HDL-C is attributable to the increased risk of obesity. This study suggests that the PBX1 gene is a possible risk factor in overweight/obese patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국영양학회 | - |
dc.title | The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 고인송 | - |
dc.identifier.doi | 10.4162/nrp.2008.2.4.289 | - |
dc.identifier.bibliographicCitation | Nutrition Research and Practice, v.2, no.4, pp.289 - 294 | - |
dc.relation.isPartOf | Nutrition Research and Practice | - |
dc.citation.title | Nutrition Research and Practice | - |
dc.citation.volume | 2 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 294 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001307984 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | High-density lipoprotein-cholesterol | - |
dc.subject.keywordAuthor | overweight/obesity | - |
dc.subject.keywordAuthor | Pre-B-cell leukemia transcription factor 1 (PBX1) | - |
dc.subject.keywordAuthor | single nucleotide polymorphism (SNP) | - |
dc.identifier.url | https://e-nrp.org/search.php?where=aview&id=10.4162/nrp.2008.2.4.289&code=0161NRP&vmode=AONLY | - |
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